Fmoc-12-amino-4,7,10-trioxadodecanoic acid

Fmoc-12-amino-4,7,10-trioxadodecanoic acid - Names and Identifiers

Name	Fmoc-12-amino-4,7,10-trioxadodecanoic acid
Synonyms	Fmoc-PEG3- CH2CH2COOH Fmoc-N-amido-PEG3-acid FMoc-NH-PEG3-CH2CH2COOH Fmoc-PEG3-propionic acid FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID Fmoc-12-amino-4,7,10-trioxadodecanoic acid N-Fmoc-12-amino-4,7,10-trioxadodecanoic acid 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid Fmoc-PEG3-OH1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid
CAS	867062-95-1

Fmoc-12-amino-4,7,10-trioxadodecanoic acid - Physico-chemical Properties

Molecular Formula	C24H29NO7
Molar Mass	443.49
Density	1.230
Melting Point	43-46°C
Boling Point	651.9±55.0 °C(Predicted)
Solubility	DMSO (Sparingly), Methanol (Slightly)
Appearance	Solid
Color	White
pKa	4.28±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Fmoc-12-amino-4,7,10-trioxadodecanoic acid - Risk and Safety

HS Code

29225090

Fmoc-12-amino-4,7,10-trioxadodecanoic acid - Reference Information

biological activity

Fmoc-NH-PEG3-CH2CH2COOH is a degradable ADC linker used in antibody drug conjugate (ADC) synthesis. Fmoc-NH-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.

Last Update：2024-04-09 21:21:28